REVIEW Peroxisome proliferator-activated receptor- : from adipogenesis to carcinogenesis
نویسندگان
چکیده
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPARhas been reported to affect cell proliferation/ differentiation pathways in various malignancies. We discuss in the present review recent advances in the understanding of the function of PPARin both cell proliferation and adipocyte differentiation. Journal of Molecular Endocrinology (2001) 27, 1–9
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